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Background Clinical studies have shown that many patients may have abnormally reduced myocardial shortening despite preserved ejection fraction (EF). Mathematical modeling explains this apparent paradox by demonstrating, that whilst myocardial shortening determines radial strain (RS), it is absolute wall thickness (AWT) rather than RS that determines EF. We sought in vivo cardiac MR (CMR) evidence to support the mathematical modeling theories.

journal of cardiovascular magnetic resonance

Are systolic function and ejection fraction interchangeable? New insights from cardiovascular magnetic resonance and in-vivo validation of mathematical models of LV function