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Methods We performed a nested case-control analysis with 1:2 matching for 39 cases of paroxysmal AF (n=28, in sinus rhythm during cardiac magnetic resonance (CMR)) and HF (n=14, AF+HF; n=3) and 78 controls with similar demographic and clinical characteristics at the baseline (Table 1). LA circumferential (short axis) and longitudinal strain rate (horizontal long axis) were measured using Multi-modality Tissue Tracking (Toshiba, Japan) from short and long-axis cine CMR images. Circumferential LA systolic dyssynchrony among 18 LA segments (6 segments x 3 slices) was evaluated as; Standard Deviation (SD) of time to pre atrial contraction Strain rate (PreA Sr) and Peak systolic strain rate (Peak Sra) (Figure 1). Similarly, longitudinal LA dyssynchrony parameters (among 6 segments) were: SD-Time to pre-atrial contraction strain rate (PreA Sr) and SD-Time to peak systolic strain rate (PeakSra). Wilcoxon-rank sum test (non-parametric) or two sample t-test (parametric) were used for comparison between the groups.

journal of cardiovascular magnetic resonance

Assessment of left atrial systolic dyssynchrony in paroxysmal atrial fibrillation and heart failure using cardiac magnetic resonance imaging: MESA study