English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Methods We prospectively enrolled 32 subjects with a genetically confirmed diagnosis of MD2. Exclusion criteria were known cardiac diseases and contraindication for CMR. We assessed left-ventricular (LV) volumes, mass and function applying state of the art cine imaging using a 1.5 T Scanner. Late enhancement imaging (LGE; slice thickness (sth) 7 mm) was performed to detect myocardial fibrosis 10 minutes after injection of gadoteridol (0.2 mmol/kgbw). We applied T1 Mapping based on MOLLI (TI native 211 ms, TI post-contrast 281 ms, TE 1.08 ms, sth 6 mm) before and 15 minutes after contrast application and assessed resultant extracellular volume fraction (ECV). Fat-water-separated imaging (GRE, TR 944.80 ms, TE 1.53-8.22 ms, sth 6 mm) was performed to identify myocardial fat deposits. Furthermore, we used H magnetic resonance spectroscopy (MRS) (TR 1600 ms, TE 35 ms, septal voxel 20 x 15 x 6 mm3) to quantify myocardial Triglycerides (MTG). Data were analyzed using cvi and standard line-fitting procedure. Results 26 data sets were totally completed (age 53.8 ± 11 y, LVEF 65 ± 0.6 %, 19 women). None of the patients had wall motion abnormalities. LGE was detectable in 6 of 28 subjects (LGE+; 3 women); the location was mostly subepicardial inferolateral basal (Figure 1). In case of LGE+, the T1-values of the enhanced regions were significantly different to remote myocardium in both the native (p = 0.03) and the post-contrast maps (p = 0.03). ECV and T1 values of the remote myocardium were not different between LGE+ and LGE negative (LGE-) groups besides to the inferolateral located ECV (25.6 % vs. 34.3 %, p = 0.03) (Figure 2). Fat deposits were noticeable in 6 of 30 subjects (all women, one with LGE +) in the apical portion of the interventricular septum. The content of MTG in LGE+ and LGEsubjects was not significant different (0.34 % vs. 0.74 %, p = 0.47).

Cardiac involvement of myotonic dystrophy type II in patients with preserved ejection fraction - Detection by CMR