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Background Heart failure (HF) is characterised by alterations in fatty acid and glucose metabolism. We aimed to determine if myocardial lipid is increased in HF with reduced (HFrEF) and preserved (HFpEF) ejection fraction (EF), and assess whether it is related to cardiac structure and function. Methods 25 HFrEF due to dilated cardiomyopathy (DCM), 18 HFpEF (defined by EF >50%, abnormal diastolic function, maximum oxygen consumption <80% predicted for age, height and gender, with a cardiac limitation in exercise) and 28 normal volunteers were prospectively recruited. All subjects underwent cardiovascular magnetic (MR) resonance at 3T for the determination of left ventricular (LV) volumes and function, and cardiac 1 H MR spectroscopy to quantify myocardial lipid/water (%). Results

Cardiac steatosis and left ventricular remodeling in heart failure with reduced and preserved ejection fraction