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Background Myocardial fibrosis is associated with abnormal cardiac remodeling and poor prognosis in patients with hypertrophic cardiomyopathy. Currently, new cardiac MRI (CMR) techniques such as T1-mapping and extracellular volume (ECV) measurement are available to quantify diffuse myocardial fibrosis. We analyzed the size of myocardial fibrosis using pre- and post-contrast T1, ECV and late gadolinium enhancement (LGE) in patients with HCM referenced to normal appearing myocardium and referenced to normal values of healthy volunteers. Methods CMR was performed in 21 patients with HCM (56±4.6 years,10 women) using a 1.5T scanner (Achieva, Philips). Myocardial lesions were assessed on 3 representative short axes of the apex, center and basis of the left ventricle by phase-sensitive inversion-recovery (PSIR) LGE-images, pre- and post-contrast T1 maps and ECV maps. Size of fibrosis was quantified in percent of left ventricular (LV) myocardium by a threshold method relative to normal appearing myocardium using a cutoff >2 SD above normal appearing remote myocardium on all images and relative to normal values assessed from 20 healthy volunteers on T1 and ECV maps. Post-contrast images were obtained after injection of 0.075 mmol/kg Gd-BOPTA. Data were analyzed using the HeAT software.

journal of cardiovascular magnetic resonance

Size of myocardial fibrosis by LGE, pre- and post-contrast T1 and ECV in patients with hypertrophic cardiomyopathy referenced to normal appearing myocardium or healthy volunteers