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Background Mapping the longitudinal relaxation time (T1) is a promising quantitative tool for the detection of myocardial pathologies either in mouse or human. T1 maps are usually obtained in 2D in order to reduce the total scan time. However, to diagnose myocardial infarction it might be useful to obtain the T1 maps in three dimensions (3D) which require a long acquisition time. In this project a new 3D T1 mapping method based on Look-Locker protocol using continuous radio frequency (RF) excitation and spiral gradient shape has been developed. This method allowed to obtain 3D maps with high spatial (200 x 200 x 300 μm) & temporal resolution (<12 min). Moreover, manganese injections demonstrated the capacity of this method to detect T1 changes in the mouse heart.

journal of cardiovascular magnetic resonance

Fast and robust 3D T1 mapping using spiral gradient shape and continuous radio-frequency excitation at 7 T : Application on cardiac Manganese Enhanced (MEMRI) MRI in mice