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Background Myocardial salvage, as determined by cardiac magnetic resonance imaging (CMR), is increasingly used as an endpoint in clinical trials. In order to calculate myocardial salvage, the infarct size needs to be related to myocardium at risk (MaR). MaR has previously been assessed by both T2-weighted imaging and contrast enhanced SSFP (CESSFP). The aim of this study was to determine how T2-weighted triple inversion recovery imaging (T2w) and CE-SSFP perform in determining MaR in multi-vendor, multi-center clinical cardioprotection trials.

journal of cardiovascular magnetic resonance

Performance of contrast enhanced SSFP and T2-weighted imaging for determining myocardium at risk in a multi-vendor, multi-center setting- data from the MITOCARE and CHILL-MI trials