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Background Women with signs and symptoms of ischemia but no obstructive coronary artery disease (CAD), often have coronary microvascular dysfunction (CMD) evidenced by the Women’s Ischemia Syndrome Evaluation (WISE) studies [1,2]. CMD is associated with higher risk of adverse cardiac events including heart failure compared to healthy women [1,2]. Elevated native T1 values are known to be suggestive of myocardial fibrosis. We hypothesized that the native myocardial T1 would be abnormally elevated indicating fibrosis in WISE subjects with CMD.

Native myocardial T1 is elevated in subjects with coronary microvascular dysfunction and no obstructive CAD