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Background The sensitivity of adenosine stress perfusion CMR scans is reduced by inadequate response to adenosine. This can be due to a variety of environmental and pharmacological factors, including recent caffeine intake. Manisty et al (2014) observed that splenic blood flow is attenuated by adenosine, as the splanchnic circulation contains vasoconstrictor adenosine receptors, and may provide a simple visual marker of adequate pharmacological stress. The aim of this study was to validate measurement of splenic switch-off (SSO) in both a quantitative and qualitative manner and examine its prevalence in an East London tertiary cardiac centre.

Splenic switch-off, a potential novel marker of lack of adenosine response: prevalence and measurement reproducibility