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Background Diabetic cardiomyopathy is a well-recognised entity, with multifactorial aetiology. We and others have previously shown impaired myocardial energetics (decreased PCr/ ATP using cardiac 31P Magnetic Resonance Spectroscopy-MRS) in patients with type II diabetes mellitus (T2DM) at rest. Furthermore, diabetic patients are known to have impaired myocardial perfusion reserve even in the absence of epicardial coronary artery disease likely due to microvascular dysfunction. However, it is unknown whether this hypoperfusion is translated to further energetic derangement at stress. Methods 27 patients (13 male, mean age 54±1.5 years; BMI 28±2.7) with T2DM and 24 healthy volunteers of similar age and BMI (13 male, mean age 51±2.6 years; BMI 26±0.84) were studied. Patients were on oral antidiabetic therapies only, with mean HBA1c 7.4±1.3% and no history of diabetic complications. Obstructive coronary artery disease (defined as> 50% lumen diameter reduction) was excluded in all patients by CT coronary angiography. Cardiac 31PMRS (3T) was performed at rest and during 8 minutes of leg exercise lying prone, with 2.5 kg weights attached to both legs. First-pass perfusion images (using a saturation recovery fast-gradient echo sequence and 0.03 mmol/kg bolus of Gadoterate meglumine (Dotarem, Guerbet LLC, France ) were also acquired at stress (3-6 minutes i.v. adenosine, 140 μg/kg/min) and rest at mid ventricular short axis. myocardial perfusion reserve index (MPRI) were measured from perfusion images. Results Left ventricular ejection fraction (LVEF) and mass index (LVMI) were similar in patients with T2DM and healthy volunteers (LVEF 70±1 vs 71±0.9%, p=0.494; LVMI 56.7 ±1.8 vs 52.6±2.4g/m 2 , p=0.168). Increases in rate pressure product with exercise (T2DM 46±36%, healthy volunteers 42±26%, P = 0.69) and adenosine stress (T2DM 40 ± 3%, healthy volunteers 39 ± 3%, P = 0.89) were similar. There was no change in PCr/ATP during exercise in healthy volunteers (rest: 2.03±0.05, exercise:

journal of cardiovascular magnetic resonance

Effect of exercise on myocardial energy metabolism and relationship between coronary microvascular dysfunction and abnormal myocardial energetics in diabetic cardiomyopathy