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Background Delayed brain development in newborns with congenital heart disease (CHD) results in increased vulnerability to white matter injury before and after cardiac surgery [1]. Doppler showing reductions in pulsatility index (PI) in the middle cerebral arteries (MCA) of fetuses with CHD is interpreted as evidence of “brain sparing physiology”. It supports the hypothesis that in utero brain dysmaturation in CHD is due to reduced cerebral oxygen delivery [2]. We were interested in the relationship between cerebral blood flow, placental pathology and white matter changes in CHD fetuses using ultrasound and MRI.

journal of cardiovascular magnetic resonance

MRI reveals increased superior vena caval blood flow in human fetuses with congenital heart disease, abnormal placental pathology and neonatal brain white matter changes