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Background Variable flip angle 3D TSE (SPACE) is a promising technique for vessel wall imaging that provides high resolution and the freedom of 3D retrospective formatting compared with 2D TSE. However it is difficult to completely suppress residual luminal blood which may mimic plaque leading to difficulties in diagnosis [Fan. JMRI. 2010:31], especially after contrast enhancement (CE). Additionally, a more efficient imaging protocol is needed that covers both carotid and intracranial arteries as atherosclerosis is a systematic disease that usually affects multiple vascular beds. The purpose of this work is to develop a 3D combined carotid and intracranial vessel wall imaging protocol with high resolution (0.7mm isotropic) and excellent blood suppression both preand post-CE.

Improved black-blood imaging using DANTE-SPACE for combined carotid and intracranial vessel wall evaluation