English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background Cardiac dysfunction is often associated with a shift in substrate preference and metabolism, but current in vivo techniques only provide information on substrate uptake. Hyperpolarized (HP) MR has the unique ability to detect metabolism in vivo and is highly specific. To evaluate the prospects for measuring myocardial substrate selection in vivo ,H P [1- 13 C]pyruvate and [1- 13 C] butyrate were co-infused into rats. Methods Pyruvate and butyrate were hyperpolarized by DNP. After dissolution the samples were automatically infused into fed or fasted animals. Myocardial metabolism was detected using a train of cardiac triggered 30 o adiabatic inspection pulses applied every 3 s at 9.4T with 1 H decoupling. Metabolite ratios were calculated to assess overall consumption of the imaging agents. Results

Real time measurement of myocardial substrate selection in vivo using hyperpolarized 13C magnetic resonance