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Patients with type 2 diabe tes mellitus (T2DM) and coronary artery disease (CAD) are at high cardiovascular risk. Both carotid intima-media thickness (CIMT) and left ventricular (LV) mass are predictors for cardiovascular events and are commonly increased in these patients. However, the mechanism of association is poorly understood. This study sought to determine that relationship and to evaluate the role of CIMT in risk prediction in T2DM patients with and without CAD. Methods Cardiovascular magnetic resonance (CMR) imaging was performed at baseline and at 2-year follow-up in 88 patients with type 2 diabetes (52 men, mean age 61 ± 8 years) including 31 patients with CAD. LV mass index (LVMI) was determined by indexing LV mass to body surface area. For carotid arteries lumen area and total vessel area were assessed and vessel wall area and vessel wall ratio (VWR = vessel wall area/body surface area) were calculated. CIMT was measured by ultrasound. Results All patients were under optimal medical treatment. Patients with and without CAD had similar age (62 ± 8 vs. 60 ± 9 years, p = 0.217) and duration of T2DM (12.6 ± 7.2 vs. 10 ± 8 years, p = 0.133). Patients with CAD showed a higher LVMI at both baseline (67.42 ± 13.21 vs. 57.75 ± 12.87, p = 0.001) and follow-up (72.43 ± 17.27 vs. 62.47 ± 15.14 g/m2, p = 0.006) compared to patients without CAD. After 2 years, both groups had a significant higher LVMI (CAD: p = 0.031; no CAD:

journal of cardiovascular magnetic resonance

Still waters run deep: progression of left ventricular mass and stagnant atherosclerosis of carotid artery in patients with type 2 diabetes mellitus and coronary heart disease - insights from a long-term CMR study