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Background Myocardial late gadolinium enhancement (LGE) imaging is conventionally acquired using a gradient-echo inversion recovery (IR-GRE) sequence 15-20 min after contrast administration. However, this method can be limited by poor breath holding or arrhythmias. Freebreathing single shot steady state free precession (SSSSFP) sequence is an alternative LGE imaging technique which can overcome some of the IR-GRE limitations but at the expense of lower resolution. The ideal imaging timing for LGE SS-SSFP, and whether it can be used interchangeably with IR-GRE has not yet been established. The aim of our study was to investigate acute and chronic infarct size: 1) Comparing LGE by SS-SSFP vs. IR-GRE at 15 min. 2) Comparing LGE SSSSFP imaging at 5 vs. 10 vs. 15 min after contrast administration vs. IR-GRE at 15 min.

Infarct size by SS-SSFP vs. IR-GRE: influence of imaging time after contrast administration and infarct age, and implications for clinical trials