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Background Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) is used as gold standard for diagnosis of myocardial infarction. However, the non-specific property of Gd overestimates the infarct size. Conversely, manganese (Mn2+) enters only the live, active cardiomyocytes via L-type Ca2+ channels. From our earlier work in animal MI models, manganese-enhanced MRI (MEMRI) has demonstrated its utility in identifying the viable, nonviable, and injured myocardium. We performed the “first in human” dual-contrast MEMRI-DEMRI to assess the efficacy of MEMRI-DEMRI to identify the periinfarct region (PIR) in patients with severe ischemic cardiomyopathy (ICM).

journal of cardiovascular magnetic resonance

Dual contrast enhanced cardiac MRI using manganese and gadolinium in patients with severe ischemic cardiomyopathy detects the peri-infarct region (PIR)