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Background In recent years in vivo cardiac DTI using stimulated echo’s (STE) has matured into a reproducible technique. However the STE approach requires two heartbeats and intrinsically has a 50% lower SNR compared to spin-echo (SE). Although the STE method allows for short TE (23 ms) it also suffers from T1 signal decay and typically 8 signal averages (16 heartbeats) are needed for a single slice acquisition. In this study we aimed to develop a SE-based cardiac diffusion MRI protocol that allows for whole heart DTI as well as intra-voxel coherent motion (IVIM) for perfusion assessment.

Feasibility of in vivo whole heart DTI and IVIM with a 15 minute acquisition protocol