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Background Probing the microscale diffusion of water informs on cardiac microstructural features such as cell density and orientation. Diffusion spectrum imaging (DSI) is widely regarded as the gold standard as it measures diffusion in am odel-free manner. However, acquisition times are prolonged due to high sampling requirements in qspace. Various methods of reducing acquisition times have been explored, including the use of echo planar imaging [1], and compressed sensing [2,3]. Here we investigate acquiring DSI data using an 8-fold accelerated diffusion-weighted fast spin echo (DW-FSE) pulse sequences versus a diffusion-weighted spin echo (DWSE) reference.

Accelerated fast spin echo diffusion spectrum imaging in the mouse heart ex-vivo