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Background We compare eight reported methods (1-8) for the analysis of cardiac perfusion flow in 3 Tesla MRI on a porcine model. Therefore, an anaesthetized healthy minipig was repeatedly scanned (x5) with a 14 day interval with Turbo FLASH at 3T. The data obtained from the images consists of the temporal course of the arterial input function (AIF) and of the tissue response function (TRF). We compared 8 analysis methods by statistical evaluation of determined perfusion flow. The analysis methods investigated were Fermi function (1), Modelfree Deconvolution (2), Modified Tofts (3), Exchange (4), Uptake (5), Tofts (6), Patlak (7), and Maximum Slope (8).

Comparing analysis methods in assessing dynamic dual bolus cardiac magnetic resonance perfusion flow