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Background Dynamic gadolinium contrast-enhanced (DCE) vessel wall MRI has recently been used to compute a set of model-based contrast kinetic parameters (e.g. K and Vp) that can well characterize the extent of inflammation in carotid plaques [1,2]. However, no studies have shown its feasibility in coronary artery wall, presumably due to the technical challenges in imaging such a constantly-moving, ultra-small structure and potential difficulty in visually distinguishing the wall from the hyperintense lumen with conventional DCE techniques. This work aimed to develop a black-blood navigatorgated ECG-triggered T1-weighted sequence for DCE MRI of coronary vessel wall.

Black-blood dynamic contrast-enhanced coronary artery wall MRI: a potential tool for kinetic-modeling-based wall inflammation assessment