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Background Bicuspid aortic valve (BAV) is a congenital abnormality that is often associated with aortic coarctation. Evidence suggests this combination may increase the risk of secondary aortic complications compared to patients with BAV alone.[1] Altered aortic hemodynamics likely induce vascular remodeling[2] and may contribute to these complications. No study has investigated the impact of aortic coarctation on aortic hemodynamics in pediatric and young adult patients with BAV using time-resolved three-dimensional phase contrast (4D flow) MRI. The aim of this study is to utilize 4D flow MRI to compare thoracic aorta flow patterns in pediatric and young adult patients with BAV with and without aortic coarctation or coarctation repair. Methods In accordance with an IRB-approved protocol, 17 patients with BAV (age = 11.9 +/- 5.3 years) who underwent cardiovascular MRI including 4D flow as part of follow-up care were included. Seven patients had aortic coarctation including 5 patients with coarctation repairs. Images were processed using in-house software for noise reduction, anti-aliasing, and eddy current correction. Flow visualization and quantification were performed in EnSight (CEI, Apex, NC). Aortic root z-scores were calculated from MRI measurements and height and weight at time of scan in EchoIMS (Merge, Chicago, IL). Flow jet pattern and helicity were assessed in the ascending aorta, aortic arch, and descending aorta. Flow jet pattern was determined by the region of peak velocity in systole corresponding to anatomically designated quadrants of

Aortic coarctation augments changes in thoracic aortic hemodynamics in pediatric and young adult patients with bicuspid aortic valve