English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Atrial fibrillation (AF) is an arrhythmia characterized by irregular electrical activity in the left atrium (LA). Thromboembolism is the most serious complication of AF, usually manifesting as stroke or systemic embolism (1). This is thought to be linked to the increased risk of thrombus formation in the LA due to a decrease in blood velocity (stasis) or flow abnormalities. A better appreciation of the underlying mechanisms and risk factors for thrombus formation in the individual patient are needed to improve risk stratification and therapy planning. Using 4D-flow MRI, time resolved blood velocity measurements can be made in patients with AF. The aim of this study was to compare LA velocity distributions in different groups of AF patients. We hypothesize that persistent AF results in more deranged LA flow patterns with reduced velocities which may be related to an increased risk of thrombus formation and thus stroke. Methods MRI data were acquired from 31 AF patients (mean age 63+/-10.5) from two groups (n=21 post-treatment, in sinus rhythm, n=10 in persistent AF). Each subject underwent gated 4D-Flow MRI on 1.5T and 3T MR systems (Siemens, Erlangen, Germany). After noise filtering, Maxwell, and eddy current correction, time resolved pathlines were emitted from planes placed manually over the pulmonary veins at the junction with the LA (Fig 1). The LA was segmented and the distribution of velocities was quantified by histogram analysis. Mean velocities were calculated for each subject group. In addition number of voxels with velocities greater than 0.2m/s was calculated. The selection of the velocity threshold was based on previous TEE results which found that systolic LA velocities less than 0.2m/s constitute a risk factor for stroke (2). Results Qualitative observation of the blood flow patterns in patients showed very different patterns between those subjects imaged in sinus rhythm and those in persistent AF. Fig 1 displays clear differences in blood flow at end systole (A,D), early diastole (B,E), and mid diastole (C,F) for a post-intervention AF patient in sinus rhythm and in persistent AF. The quantitative results from all subjects are summarized in fig 2. Patients with persistent AF had a mean blood flow of 0.14±0.03m/s, lower than AF patients in sinus rhythm (0.19±0.04m/s, p=0.006). 14% of the velocity values for patients in AF were greater than 0.2m/s, lower than patients in sinus (35%, p=0.004).

Quantification of left atrial flow velocity distribution in atrial fibrillation using 4D flow MRI