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Background Enlargement of the aorta or main pulmonary artery (MPA) is associated with cardiopulmonary disease, and an increased MPA-to-ascending aorta ratio is associated with pulmonary hypertension. We sought to determine mean and upper 90th percentile (p90) diameters of the thoracic and abdominal aorta and MPA in a longitudinally-followed adult cohort without clinical cardiopulmonary disease. Methods 1794 Framingham Heart Study Offspring cohort members (65±9 yrs, 844 men) underwent ECG-gated, free breathing T2-weighted black-blood TSE at 1.5T (Philips Gyroscan NT, TR=3RR, TE=45ms, trigger delay=75ms (thorax) or 125ms (abdomen), 1.03x0.64-mm 2 in-plane resolution, THK=5mm, Gap=5 (abdomen) or 10mm (thorax)). Ascending (ASC) and descending thoracic (DTA) aortic and MPA diameters were measured at MPA-bifurcation level, abdominal (ABD) aorta was measured 5 mm above renal artery origins. We determined sex-specific mean, SD and p90 values for vessel diameters and MPA/ASC ratio in a healthy referent group free of hypertension (SBP≥140 or DBP≥90 mmHg or on medication), obesity (body mass index≥30 kg/m 2 ), emphysema, prevalent myocardial infarction or heart failure, and any smoking history. Men were compared to women using 2-sample t test. We also indexed vessel diameters to sex-and-vessel specific allometric powers of height (HT b ); b’s were determined by linear regression of log(HT) to log(diameter). Indexation to HT b was selected since indexation to HT or body surface area (BSA) resulted in significant inverse correlations of vessel diameters to HT and/or BSA.

journal of cardiovascular magnetic resonance

Normal reference values for thoracic and abdominal aorta and main pulmonary artery dimensions by cardiovascular magnetic resonance: the Framingham heart study