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Background Cardiovascular Magnetic Resonance (CMR) based assessments of area-at-risk and salvageable myocardium on the basis of myocardial edema in the setting of acute coronary syndrome is of significant clinical interest. However, their dependence on the choice of acquisition method and time to imaging has not been studied. In this study, we investigated the temporal evolution of myocardial edema during ischemia and reperfusion phases using both T2 maps and T2-STIR images. Methods Canines (n=10), subjected to I-R injury, underwent CMR (1.5T) before ischemia (baseline), during ischemia and on days 2, 5, and 7 post-reperfusion. T2-preapred SSFP (T2-preparation durations = 0, 24 and 55 ms; TR/TE =

CMR-based assessment of myocardial edema in the setting of ischemia and reperfusion