English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Interstitial deposition of amyloid fibrils in the heart causes thickening of atrial and ventricular walls. Although the presence of abnormal late gadolinium enhancement (LGE) in ventricular myocardium is well described, the significance of atrial LGE is less clear. The aim of this study is to describe the prevalence of atrial LGE in cardiac amyloidosis and to investigate potential associations with disease severity. Methods We retrospectively reviewed consecutive patients referred for CMR due to clinically suspected cardiac amyloidosis. The final diagnosis of cardiac amyloidosis was established in the presence of a positive cardiac biopsy and/or a typical pattern of diffuse, predominantly subendocardial left ventricular (LV) LGE. Clinical data (including EKG, pulmonary capillary wedge pressure from cardiac catheterization and brain natriuretic peptide [BNP] serum levels) and subsequent events (death or hospitalization) were recorded. Indexed LV and right ventricular (RV) volumes and ejection fractions, LV mass, LV basal anteroseptal and inferolateral enddiastolic wall thicknesses, and left atrial dimensions were determined from standard cine CMR images. In cardiac amyloid patients, the septal E/E’ ratio, as an index of LV filling pressures, and diastolic function were determined from Doppler echocardiography. Diastolic function was classified as grades 0 (normal), I (impaired relaxation pattern), II (pseudonormal pattern), and III (restrictive pattern). Results We included 125 patients (85 males [68%], age 63±13 years) referred for CMR (59 (47%) at 1.5, 66 (53%) at 3.0 Tesla), of which 51 (40.8%) were diagnosed of cardiac amyloidosis. The prevalence of atrial LGE was markedly higher in those with a diagnosis of cardiac amyloid (86.3% vs 13.5%, p<0.001). Including all 125 patients, atrial LGE was independently associated with the diagnosis of cardiac amyloid in a multivariate analysis including all CMR variables (odds ratio [OR] =26.9, 95% confidence intervals 8.1-88.7, p<0.001). In the group of patients with cardiac amyloidosis, the presence of atrial LGE was associated with age (68 ± 12

Atrial delayed enhancement is associated with the severity of diastolic dysfunction in cardiac amyloidosis