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Background Reference pre- and post-contrast T1 values of myocardium have been reported at 1.5T but those values at 3T have not been fully established. Additionally, the physical properties of gadolinium contrast agents significantly affect the myocardial voxel T1 value. There have been two different contrast injection methods in the literatures. The aim of our study was to establish pre- and post-contrast reference T1 relaxation times of normal myocardium at 3 Tesla MR using shortened modified look-locker inversion recovery (sh-MOLLI) and to assess the effects of contrast injection methods on T1 values. Methods Myocardial T1 mapping at 3 Tesla MR was obtained using sh-MOLLI from 22 healthy volunteers (15 males and 7 females, mean age, 30.9 ± 4 years), who were randomly assigned to group 1 (n = 11) and group 2 equally. The dose of contrast agent was divided to allow perfusion protocols with 60 sec delay before the second injection in group 2, whereas, the single injection of same dose in group 1. For each patient, T1 mappings at three short-axis levels were performed consecutively at precontrast, 2 min, 5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the single injection in group 1 and the second injection in group 2. T1 values of myocardium were measured in six segments per each level and sliceaveraged myocardial T1 relaxation times were calculated.

journal of cardiovascular magnetic resonance

Shortened modified look-locker inversion recovery for myocardial T1 mapping in healthy volunteers: determination of reference T1 relaxation times at 3 Tesla MR according to different contrast injection methods