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Background Fibrosis is thought to play an important role in the pathogenesis of the adverse sequelae of hypertrophic cardiomyopathy (HCM). Late gadolinium enhancement (LGE) cardiovascular magnetic resonance detects replacement fibrosis but cannot presently detect interstitial fibrosis. The latter is thought to be a very early feature of HCM and can be triggered by inflammation, which can also expand the size of the myocardial interstitium. We sought to determine whether extracellular volume (ECV) mapping by T1-relaxometry in concert with T2mapping can identify interstitial changes in HCM and whether these were related to myocardial edema.

Role of T1 and T2-mapping in assessing the myocardial interstitium in hypertrophic cardiomyopathy: a cardiovascular magnetic resonance study