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Background Ultrasmall superparamagnetic particles of iron-oxide (SUPIO) particles can be used as a magnetic resonance imaging contrast (MRI) agent. Due to their dextran coating and small diameter (<30 nm), they are phagocytised by inflammatory cells [1]. The aim of this study was to assess whether a novel acquisition/registration USPIO-MRI protocol could be used to assess myocardial cellular inflammation. Myocardial infarction and cardiac surgery was used to model myocardial inflammation [2]. An influx of macrophages can be seen in post-mortem histology, however the dynamics of in vivo patho-physiology is uncertain [3].

Quantitative myocardial inflammation assessed using a novel USPIO-Magnetic Resonance Imaging acquisition and analysis protocol