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Methods Fifty-nine patients with rTOF (median age 28 years, range 15-69) underwent cardiovascular magnetic resonance (CMR) from 2008-2009 and completed the Short Form 36 (a validated quality of life assessment). A midventricular short-axis slice was analyzed for left ventricular global circumferential strain (LVGCS) with feature tracking software (TomTec, Unterschleissheim, Germany). A four-chamber slice was analyzed for left ventricular longitudinal strain (LVGLS), and right ventricular longitudinal strain (RVLS), using the three segments of the right ventricular free wall. A subset of 30 patients was re-analyzed for intraobserver and interobserver variability. The physical component summary (PCS) and subscales of physical functioning (PF), role-physical (RP) and general health (GH) were chosen for analysis, and age-adjusted z-score ≤-1 was considered a clinically significant decreased quality of life.

Right ventricular free wall strain predicts quality of life in repaired tetralogy of Fallot