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Background CMR measurement of mitral inflow velocities for the assessment of diastolic function is often infeasible in patients with dyspnea - patients who may benefit the most - due to their inability to breath-hold. Although real-time phase contrast (RT-PC) imaging may overcome this limitation, it has not been systematically evaluated. The objective of this study was to assess the accuracy of RT-PC for the measurement of mitral inflow velocities against segmented PC CMR and Doppler echocardiography. Methods 37 healthy volunteers (aged 28 ± 10 years, 20 males) had echo and CMR studies within a week. Early (E) and late (A) mitral inflow velocities were measured by echo, segmented, and RT-PC CMR (Figure). The E and A velocities were obtained by averaging data from 2 heart beats by RT-PC and 3 heart beats by echo. RT-PC parameters were: TR/TE = 14.0ms/2.3ms, water excitation flip angle=25○ ,10mm slice, 90 x128 matrix, EPI factor=15, TSENSE rate=3, and VENC=150cm/s. Shared velocity encoding was used to achieve an effective temporal resolution of 28ms, but true temporal resolution was 56ms. Retro-gated segmented PC acquisition parameters: TR/TE = 4.5/1.9ms, 10mm slice, 100 x 192 matrix, TSENSE rate=3, VENC=150cm/s, true temporal resolution 36ms. E and A velocities, and E/A ratios between RT-PC and segmented PC CMR or Doppler echocardiography were compared using paired t-tests. Agreement between the techniques was assessed using concordance correlation coefficients and Bland-Altman analysis.

journal of cardiovascular magnetic resonance

Diastolic function imaging: a comparison of real-time phase contrast magnetic resonance (CMR) imaging with segmented phase contrast CMR and Doppler echocardiography