English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Abdominal aortic aneurysms (AAA) are a major cause of morbidity and mortality in the US. The most common location of AAA is the infrarenal abdominal aorta where oscillatory flow is present over the cardiac cycle, figure 1. Oscillatory flow is known to initiate an inflammatory response in endothelial cells. Patients with lower extremity traumatic amputations have a 5-fold increase in AAA occurrence unrelated to co-morbidities. The objective of the study is to determine the amount of infrarenal aortic oscillatory flow changes between baseline and acute occlusion of arterial blood supply to a lower extremity (a condition mimicking a lower extremity amputation). Methods Six healthy volunteers underwent MRI exam which included non-contrast MRA and PCMR measurement in the abdominal aorta. PCMR measurements were done at baseline and during 3-4 minutes of acute arterial occlusion using a blood pressure cuff to mimic a unilateral above knee (AKA) and bilateral above knee (Bi-AKA) amputation. PCMR scans were acquired perpendicular to the aorta at 2 levels: below the renal arteries and immediately above the aortic bifurcation. PCMR was used to create waveforms showing flow versus time over the cardiac cycle, figure 1. In all subjects, we computed the percent of retrograde flow over the cardiac cycle at baseline and during the two acute occlusion conditions. Results The retrograde flow was 17.9%+/-1.6 at baseline. AKA resulted in a significant increase in retrograde flow above the aortic bifurcation, the most common site of AAA formation (26.3%+/-4.2 p<0.05). Bi-AKA further increased retrograde flow to 30.1%+/-3.9 p<0.05. Our results suggest that mimicking a traumatic amputation produces a significant increase in infrarenal retrograde aortic blood flow, leading to an increase in oscillatory wall shear stress, a precursor of endothelial dysfunction. Additionally, the velocity profiles above the aortic bifurcation showed that during unilateral AKA, the diastolic reversal of blood flow was more pronounced on the side of the amputation. These findings agree with

Lower extremity amputation increases oscillatory flow in the infrarenal aorta: A new potential risk factor for abdominal aortic aneurysm development