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Summary Post-gadolinium bolus T1 mapping was used to assess interstitial myocardial fibrosis in a group of patients with severe aortic stenosis. The changes identified were correlated with regional contractile perfomance as assessed by CSPAMM tagging. T1 mapping proved to be a practical feasible approach for assessing diffuse fibrosis. Background Aortic stenosis (AS) is associated with increased interstitial myocardial fibrosis (IMF). This is detectable by cardiovascular magnetic resonance (CMR) after gadolinium infusion. T1-mapping-derived partition coefficients (l) and extracellular volume fractions (Ve) have also been shown to correlate with IMF after a simple bolus administration of gadolinium. We hypothesized that the l and Ve would also detect interstitial expansion in severe AS patients compared to healthy controls and that these measures would correlate with abnormal myocardial strain using a high temporal-resolution tagging sequence. Methods

Bolus administration T1 mapping as a marker of interstitial myocardial fibrosis in severe aortic stenosis