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Summary Using 3T MRI combined with isometric handgrip exercise to quantify coronary endothelial-dependent vasoreactivity, we observed significantly reduced coronary EndoFx in overweight/obese individuals compared to normal weight adults and detected a significant inverse relationship between BMI and % CSA, a measure of endothelial independent vasoreacivity. Background Although obesity is a known risk factor for future cardiovascular events [1], its relationship to coronary endothelial function, which is impaired in early atherosclerosis, is not completely understood. By means of previously described non-invasive 3T MRI methods combined with isometric handgrip to assess endothelialdependent coronary vasoreactivity [2], we sought to test the hypothesis that coronary endothelial function (EndoFx) is reduced in obese, non-diabetic individuals when compared to healthy non-obese volunteers and that body mass index (BMI) is inversely related to EndoFx. Methods 14 overweight and obese non-diabetic adults defined as BMI >25 (BMI=32.3±4.4, mean±SD, 9 women) and 10 healthy non-overweight adults (BMI=22.9±2.8, 7 women) with no history of cardiovascular disease or risk factors were imaged using a 3T MRI scanner (Achieva, Philips, Best, NL) and a 32-element cardiac coil for signal reception. To measure endoFx, spiral coronary MRI was performed before and during isometric handgrip exercise, an endothelial-dependent stressor, and coronary cross-sectional area (CSA) and coronary blood velocity (CV) changes were measured and coronary blood flow (CBF) calculated as previously reported [2]. Results

Coronary endothelial function using 3T MRI is inversely related to body mass index