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Summary We sought to determine, in patients with LDL <100mg/ dL, if abnormalities in lipid sub-fractionation are associated with reduced myocardial perfusion reserve (MPRi; a surrogate for microvascular dysfunction). Despite the absence of a correlation between low-density lipoprotein and MPRi, a significant inverse relationship between sub-fractions of LDL and MPRi exists. Background Abnormalities in total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG) are associated with microvascular dysfunction and are the primary target for treating atherosclerosis. Newer lipid assays allow for measurements of lipoprotein sub-fractions; however, their impact on microvascular function remain unknown. We sought to determine, in patients with LDL <100mg/dL, if abnormalities in lipid sub-fractionation are associated with reduced myocardial perfusion reserve (MPRi; a surrogate for microvascular dysfunction). Methods

journal of cardiovascular magnetic resonance

Lipid sub-fractionation predicts worsening myocardial perfusion reserve in patients with low-density lipoprotein less than 100mg/dL: a regadenoson dardiac magnetic resonance study