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Background Transmyocardial delivery of stem cells in the setting of acute myocardial ischemia has shown promise to prevent adverse ventricular remodeling1. However, the efficacy is limited by poor cell retention and low survival rates, even for autologous cells. Intrapericardial delivery of microencapsulated stem cells may offer a local and minimally invasive route to enhance cell survival and retention. In this study, we assess the delivery of human mesenchymal stem cells (hMSCs) in a radiopaque microcapsule to the pericardium using x-ray fused with magnetic resonance imaging (XFM) in a porcine model.

XFM-guided delivery of imaging-visible human mesenchymal stem cells into the pericardial space in a porcine model