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Background Myocardial oedema, myocardial salvage and myocardial salvage index, have been described as markers of prognosis and surrogate markers for clinical trials. The timecourse of oedema following revascularised MI has been described in the first 6 months following PPCI but there is wide disagreement on the time to complete resolution. We therefore aimed to determine the time-course of post infarct myocardial oedema using serial T2weighted CMR imaging for the first year following MI. Methods 16 patients with acute ST-elevation MI who underwent primary PCI with stent implantation within 12 hours of symptom onset were recruited. Patients were scanned on days 1, 3, 10, 20, 96 and 384 days following their PPCI with a 1.5T Philips Achieva (Philips Medical Systems). Images were obtained as continuous short-axis stacks covering the left ventricle with a slice thickness of 8mm and gap of 2mm. Myocardial oedema was assessed at all time points using T2-weighted triple inversion turbo spin echo STIR imaging (TE 80, TR 1667). Image analysis was performed using dedicated software, CMR42 (Circle CVI, Calgary, Canada). Scar and oedema volumes were calculated by manually drawing endocardial and epicardial contours followed by semi-automated selection of normal remote myocardium per slice. The oedema was described as >2SD in signal intensity from remote normal myocardium. Values are expressed as a percentage of the LV mass (% LVM). Results

The natural time course of myocardial oedema in the 12 months post ST-elevation MI in patients treated with primary angioplasty