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Background Assessment of regional ventricular deformation is more sensitive than ejection fraction (EF) for detecting myocardial dysfunction. We sought to compare a local sinewave modelling (SinMod) method with the more established harmonic phase analysis (HARP) technique, for assessment of Lagrangian left ventricular (LV) peak systolic circumferential strain (ecc) from tagged cardiovascular magnetic resonance images, in patients with cardiomyopathies and healthy volunteers. The variability and rapidity of each technique, and the effect of contrast, were also assessed. Methods Sixty participants (15 each with hypertrophic, dilated or ischaemic cardiomyopathy and 15 healthy controls) with a wide range of LV ejection fraction (14-78%) underwent spatial modulation of magnetization tagging of a mid-ventricular short-axis slice at 1.5 Tesla. Global and segmental peak transmural ecc were measured using HARP and SinMod. Repeated measurements were performed on 15 randomly selected scans (25%) in order to assess observer variability. Tagged images were acquired pre- and post-contrast in 10 additional patients in order to assess the effect of contrast. Results

journal of cardiovascular magnetic resonance

Comparison of local sine wave modelling with harmonic phase analysis for the assessment of circumferential myocardial strain from tagged cardiovascular magnetic resonance images