English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background In myocardial perfusion imaging (MPI), highly accelerated acquisition can be used towards reducing the compromises in the image quality (spatio-temporal resolutions, volume coverage, SNR) routinely observed with the current clinical protocols. In this study, we demonstrate the feasibility of a recent accelerated dynamic MRI scheme, k-t SLR (based on sparse and low rank properties) (Lingala et al. ‘11) in free breathing MPI. k-t SLR exploits natural redundancy in MPI by using (a) the high degree of temporal correlations, and (b) the sparse properties of the images in appropriate transform domains (finite difference transforms along space and time). It poses the recovery as a spectral regularization problem, allowing for the use of fast optimization solvers and flexible non-Cartesian sampling schemes. Here, we also include information from multiple coils to improve data consistency in the recovery. We demonstrate high accelerations with both rest and stress data sets. Comparisons are made with existing schemes such as spatio-temporal constrained reconstruction (STCR, Adluru et al ‘09) and k-t SPARSE/ SENSE (Otazo et al ‘10). Methods A radial FLASH saturation recovery sequence (TR/ TE~2.5/1.3ms) was used. 3 slices with 72 rays uniformly spaced within a frame and offset between frames were acquired. Datasets for 3 normal subjects and 1 patient with disease were imaged in rest and adenosine stress. These 72 ray sets correspond to an acceleration of R ~ 3.4 compared to Nyquist sampling. Residual streaking was resolved in these sets by using a standard STCR algorithm and formed the ‘reference’ images. We performed retrospective undersampling using 21 rays (R~12) and 18 rays (R~14) respectively for the stress and rest sets and reconstructed with multi-coil k-t SLR, multi-coil STCR and multi-coil k-t SPARSE. Golden ratio, uniform and random sampling were respectively used for k-t SLR, STCR and k-t SPARSE/SENSE, based on experiments of which sampling pattern was best for each algorithm. Validation was based on two metrics that depict the accuracy of the myocardial perfusion dynamics (see fig 2). The first metric gives a measure of the myocardial slope while the second gives an aggregate measure of several factors such as peak enhancement, sensitivity to breathing motion and temporal blur. Results

Accelerated imaging of rest and stress myocardial perfusion MRI using multi-coil k-t SLR: a feasibility study