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Summary Rodent models of heterotopic cardiac transplantation are important for gaining a better understanding of heart allograft rejection. This study compared a working heart (WkHt) transplant model, which have developed by our laboratory, with the traditional non-working heart (Non-WkHt) model using cardiac MRI (CMRI) and pathological evaluation. Our results indicate that the physiological hemodynamic loading significantly impacts graft immune cell infiltration and myocardial function. Our WkHt transplant model with intact pulmonary circulation, retains hemodynamic loading close to that of native heart, and is thus more appropriate for both functional and immunological studies, especially for developing the clinically relevant CMRI techniques for comprehensive evaluation of the heart graft. Background The traditional heterotopic heart transplantation rodent model [1,2] lacks blood flow toward left ventricle (LV) and the graft does not pump blood, and therefore is a non-working heart (Non-WkHt). We have developed a new heterotopic working heart (WkHt) transplant model with intact pulmonary circulation to study cardiac allograft rejection.[3] In this study, we used combinations of pathology and multi-parameter CMRI, such as cine, Tagging, and T1/T2, to comprehensively evaluate the impact of physiological loading on the myocardial function, immune cell infiltration and graft pathophysiological condition of these 2 models.

journal of cardiovascular magnetic resonance

The impact of physiological loading on immune cell infiltration and myocardial function evaluated by cardiac MRI: a comparison between non-working heart and working heart transplant models