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By cardiac MRI we investigated the relationship of resting myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM) patients to important parameters of disease. MBF was quantified on pixel-by-pixel basis in 804 segments in 70 patients. Relative MBF negatively correlated with left-ventricular (LV) wall thickness (p<0.001), extent of myocardial delayed enhancement (MDE; p<0.001), edema (T2 bright; p<0.001), T2 dark signal (p<0.001) and age (p=0.032), but not LV outflow gradient (p=0.901). Different perfusion patterns in segments with reduced and elevated resting perfusion were observed, which may represent different stages of HCM.

journal of cardiovascular magnetic resonance

Reduction of relative resting myocardial blood flow is related to myocardial delayed enhancement, T2-signal abnormalities, left-ventricular wall thickness and age in patients with hypertrophic cardiomyopathy