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Summary Tissue oxygenation response to adenosine stress in patients with hypertrophic cardiomyopathy (HCM) is blunted compared to athletes and normals. Myocardial tissue hypoxia during stress in HCM may potentially contribute to the increased exercise related deaths in this condition. Background By exploiting the paramagnetic properties of deoxyhemoglobin, blood oxygen level-dependent (BOLD) MRI can detect myocardial ischemia in patients with coronary artery disease. However, little is known about myocardial tissue oxygenation in pathological left ventricular hypertrophy (e.g. HCM) or physiological hypertrophy (e. g. elite athletes). Perfusion studies have shown that patients with HCM show evidence of microvascular dysfunction, however, whether this leads to de-oxygenation and ischemia is unclear. Methods

journal of cardiovascular magnetic resonance

Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death