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Summary We demonstrate the feasibility of 3D myocardial perfusion CMR at 3 Tesla against invasive measures of myocardium at risk and ischaemic burden (Duke Jeopardy Score) in fifty-three patients for the detection of flowlimiting coronary artery disease and show good agrement between the techniques (Pearson r=0.82). This led to the novel use of this technique as a non-invasive method of detecting ischaemic burden and myocardium at risk for the purpose of serial studies, guiding revascularisation and risk stratification. Background Three-dimensional (3D) myocardial perfusion cardiovascular magnetic resonance (CMR) overcomes the limited spatial coverage of conventional perfusion CMR methods. It permits whole heart coverage and can establish an estimation of myocardium at risk and ischaemic burden, which has not been validated as yet. For invasive estimation of ischaemic burden, semi-quantitative angiographic scores including the Duke Jeopardy Score have clinical legitimacy as the magnitude of myocardium at risk due to severe coronary stenosis is associated with an adverse prognosis. The Duke Jeopardy score combines assessment of stenosis severity and location.

journal of cardiovascular magnetic resonance

Validation of dynamic three-dimensional whole heart magnetic resonance myocardial perfusion imaging at 3.0 Tesla against the duke jeopardy score to assess myocardium at risk