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Background T1 mapping of the left ventricle is routinely performed using Modified Look-Locker Inversion Recovery (MOLLI) [1] in a variety of disease settings [2]. MOLLI requires relatively long breathholds, and consequently sequences of MOLLI images may be misregistered due to respiratory drift. We sought to develop a T1 mapping sequence that would not require breathholding and would not have misregistration problems. We used kspace segmentation and navigator gating to eliminate respiratory artifact, and compressed sensing [3] (CS) to accelerate image acquisition. CS utilizes undersampling in k-t space along with nonlinear iterative image reconstruction. CS is well-suited to Look-Locker imaging because these images, which vary smoothly from one inversion time to the next, exhibit time-domain sparsity.

Accelerated and navigator-gated look-locker imaging for cardiac T1 Estimation (ANGIE) with reduced motion artifact