English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Globally increased myocardial extracellular volume fraction (ECVF) has been associated with diffuse myocardial fibrosis. ECVF can be estimated using blood and tissue concentrations of gadolinium contrast agent, [Gd], which are calculated using baseline and post-contrast T1 values [1]. To date, T1 quantification has been limited to the left ventricle (LV) with moderate spatial resolution (~2 mm) and long imaging windows (>200 ms) to accommodate breath-hold acquisitions. These methods have insufficient spatial resolution to image the relatively thin-walled right ventricle (RV). A new cine-imaging approach for the measurement of contrast agent concentration and ECVF using saturation-recovery preparation is evaluated in the LV and RV. Methods A saturation-recovery gated-segmented cine SSFP sequence, similar to the multi-contrast late enhancement imaging method [2], provides a short acquisition window (< 50 ms) enabling end-systolic imaging and higher spatial resolution (~1 mm). Bloch equation simulations of the sequence were used to generate a look-up table to relate the measured ratio of post- to pre-contrast image intensity to the tissue concentration of contrast agent (CLAIR - Contrast Level Assessment using Intensity Ratios). Short axis images were acquired in 9 subjects from an ongoing study of heart failure (Alberta HEART), with contrast-enhanced images at 15 min post 0.15mmol/kg Gadovist. Typical CLAIR pulse sequence parameters: FOV=300mm, 256 matrix, 8 mm slice, flip angle=73°, TE=1.66ms, TR=3.32ms, VPS=14, TI=300ms. Average LV [Gd] in subjects was compared to values obtained using a saturation-recovery SSFP T1-mapping sequence [3] calculated using [Gd] = ΔR1/r (ΔR1 =

Imaging contrast agent concentration and extracellular volume fraction in the right ventricle