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Background A T1 nanoparticle contrast agent showing high r1 relaxivity is desired to provide more sensitive molecular/ cellular imaging with reduced Gd dose, and may have more clinical utility than T2* (e.g., iron-based) approaches. Tethering multiple Gd-chelates to a supramolecular platform is a promising strategy to increase r1 relaxivity, as rotational correlation time of the Gd ions can become significantly larger which is highly favorable for efficient r1 relaxivity. Here we utilize a small heat shock protein cage (Hsp) with a 12nm exterior diameter and a 9nm interior cavity, as a platform to anchor Gd-DTPA.

Gd-based protein cage nanoparticles provide enhanced r1 relaxivity and detect experimental atherosclerosis