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Methods 15 patients with Marfan syndrome and no history of prior aortic dissection or surgery, and 18 healthy volunteer controls matched for age, sex and height underwent CMR at 3T (Siemens, Erlangen). Time-resolved, 3D velocity-encoded and magnitude data were acquired using a phase contrast CMR sequence (Figure 2). Each dataset was evaluated for flow disturbance by two independent observers, experienced in aortic flow visualisation, and blinded to patient identity.

Visualisation of aortic flow disturbance in Marfan syndrome by 4D phase-contrast CMR