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While previous studies suggest that the peri-infarct zone (PIZ) may be an important arrhythmogenic substrate and may be associated with an unfavorable outcome post-MI, to date, there is no convincing mechanistic explanation to support that relationship. Systemic inflammatory response (SIR) in the acute phase post-MI has also been associated an adverse prognosis.Furthermore, a strong SIR may lead to greater heterogeneity of the infarcted myocardium. We hypothesized that the PIZ extent would be associated with the severity of the post-MI SIR. We further sought to determine if prognostic information provided by PIZ extent and SIR would complement classical markers of adverse outcome post-MI.

journal of cardiovascular magnetic resonance

Characterization of peri-infarct zone by CMR is a robust predictor of major adverse events and is strongly associated with systemic inflammatory response post-myocardial infarction