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Background Organ perfusion can be quantified by direct calibration of relative perfusion images using absolute blood volume (ml/100g) [1]. It is well known that for an intravascular gadolinium-based T1 shortening contrast agent, the parenchymal T1 change reflects tissue blood volume [2].However, to accurately quantify blood flow from blood volume, we must describe the compartmentalization effects of intrato extra-vascular water exchange [2,3].

A protocol for the measurement of myocardial blood volume and water exchange