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Methods 223 consenting nondiabetic, normotensive volunteers without clinical cardiovascular disease or echocardiographic abnormalities (124 females, 116 hyperlipidemic (42 treated), age: 58.6+/-14.9yrs, BMI: 24.8+/-3.3 (24 with BMI>28) were studied. CMR studies were performed on a 1.5 Tesla MR scanner (Siemens, Germany) using a phased array surface-coil and a spine-coil array. PWV was assessed using breath-held through-plane phase-contrast gradient echo imaging of the ascending and descending aorta at the pulmonary artery level with a VENC of 1.5 m/sec, temporal resolution of 24 frames per second and slice thickness of 6mm. Aortic images were manually contoured using QFlow (Medis, Leiden, the Netherlands) and PWV determined by the ratio of the distance between the ascending and descending aortic plane along a candy-cane view over the time of pressure pulse travel in between. Pearson and Spearman correlation coefficients were used to examine associations between PWV and age, CCTscore, blood pressure (BP), rate pressure product(RPP), lipid levels, and cardiac function.

Correlates of Aortic Pulse wave velocity measured by cardiac MRI