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Background  Arterial stiffness is considered as an independent predictor of cardiovascular mortality, and is increasingly used in clinical practice. This study aimed at evaluating the consistency of the automated estimation of regional and local aortic stiffness indices from cardiovascular magnetic resonance (CMR) data.    Results  Forty-six healthy subjects underwent carotid-femoral pulse wave velocity measurements ( CF_PWV ) by applanation tonometry and CMR with steady-state free-precession and phase contrast acquisitions at the level of the aortic arch. These data were used for the automated evaluation of the aortic arch pulse wave velocity ( Arch_PWV ), and the ascending aorta distensibility ( AA_Distc, AA_Distb) , which were estimated from ascending aorta strain ( AA_Strain ) combined with either carotid or brachial pulse pressure. The local ascending aorta pulse wave velocity  AA_PWVc  and  AA_PWVb  were estimated respectively from these carotid and brachial derived distensibility indices according to the Bramwell-Hill theoretical model, and were compared with the  Arch_PWV . In addition, a reproducibility analysis of  AA_PWV  measurement and its comparison with the standard  CF_PWV  was performed. Characterization according to the Bramwell-Hill equation resulted in good correlations between  Arch_PWV  and both local distensibility indices  AA_Distc  (r = 0.71, p < 0.001) and  AA_Distb  (r = 0.60, p < 0.001); and between  Arch_PWV  and both theoretical local indices  AA_PWVc  (r = 0.78, p < 0.001) and  AA_PWVb  (r = 0.78, p < 0.001). Furthermore, the  Arch_PWV  was well related to  CF_PWV  (r = 0.69, p < 0.001) and its estimation was highly reproducible (inter-operator variability: 7.1%).    Conclusions  The present work confirmed the consistency and robustness of the regional index  Arch_PWV  and the local indices  AA_Distc and AA_Distb  according to the theoretical model, as well as to the well established measurement of  CF_PWV , demonstrating the relevance of the regional and local CMR indices.

journal of cardiovascular magnetic resonance

Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study